gallbladder disorders. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. These side effects may be mild or severe. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Merlin Annie Raj, RD (Registered Dietitian), Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. Can you drink alcohol while taking milk thistle? Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. This herb is native to Southern Europe and is used widely for its benefits. Toxicity is also possible if too much milk thistle is taken. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. One of milk thistle's traditional uses is easing indigestion. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. In a 2016 study, researchers fed rats a high-cholesterol diet. [Database subscription]. Cochrane Database Syst Rev. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. Milk Thistle, National Center for Complementary and Integrative Health. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. milk thistle. Available for Android and iOS devices. Milk thistle can also cause an allergic reaction in some people. Fried MW, Navarro VJ, Afdhal N, et al. One study questioned the benefits of milk thistle for liver diseases. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. However, more direct research is warranted in this regard. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti . The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A double-blind controlled study. Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. Rev Diabet Stud. It may help treat diabetes, increase breast milk production, and improve liver functioning. Keep in mind, though, that it is unknown if milk thistle tea provides the same suggested benefits as milk thistle supplements. Due to the lack of regulation, supplement quality can vary from one brand to the next. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). Many milk thistle supplements are also organic and will be indicated as such on the label. We encourage you to discuss any decisions about treatment or care with your health care provider. Moderately clinically significant. When choosing a new supplement, it is vital that you carefully read the label's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Consult your doctor or pharmacist for more details. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. Who should not take Milk Thistle Capsule? Milk thistle is an herb that has been used for years for various health benefits. Together, you can make shared, well-informed decisions. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. Highly clinically significant. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. In:Drugs and Lactation Database (LactMed). Milk thistle. Tajmohammadi A, Razavi BM, Hosseinzadeh H. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. Seeff LB, Curto TM, Szabo G, et al. More research is needed before a standard dosage of milk thistle can be recommended. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Eur Endocrinol. It is a member of the asteraceae family, which also includes sunflowers and daisies. Milk thistle is native to Europe and was introduced into North America by early colonists. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. Hence, stay safe and avoid use. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. What Is Complementary, Alternative, or Integrative Health? Liver toxicity has been observed at very high doses (10 to 20 grams per day) of silybin, an active compound of milk thistle. The terms milk thistle and silymarin are often used interchangeably. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. There is no standard dose of milk thistle, so it is best to read the dosage suggested on the packaging. Some research also states that overall, milk thistle may not pose a great risk for drug interactions in humans (13). Dupuis ML, Conti F, Maselli A, et al. Other potential benefits include . Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Hepatology. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration.4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. The active ingredient in milk thistle is called silymarin. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. The mention of any product, service, or therapy is not an endorsement by NCCIH. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. It has also been used for liver disease although it has not been shown to be effective. Gillessen A, Schmidt HH. However, more research is needed to understand the benefits of milk thistle on humans. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. For centuries, this herb has been used in fighting hangovers (9). This article will explore the potential uses of milk thistle. The name milk thistle is associated with the legend of Mother Mary. A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. nausea, loss of appetite. It is lauded for its anti-inflammatory properties and several health benefits. Consult your doctor before using this product. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. It could also have similar effects on the body to estrogen. This is not a complete list of possible side effects. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Milk thistle may interact with certain medications. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. Call your doctor for medical advice about side effects. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. List Milk Thistle Capsule side effects by likelihood and severity. Taking it along with estrogen pills might reduce their effectiveness. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. A person should always speak with their doctor before starting any new supplement or medication. The active ingredient in milk thistle may help to reduce inflammation. You may report side effects to FDA at 1-800-FDA-1088. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Verywell Health's content is for informational and educational purposes only. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. Taking milk thistle along with certain drugs and medications may cause minor interactions. Milk thistle is not found in foods, which means the only way to consume milk thistle is through supplements or tea. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. This is not a complete list of side effects and others may occur. Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Before using this product, tell your doctor or pharmacist of all the products you use. JAMA. Check with your physician if you have any of the. However, many of these potential benefits are not backed by science. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. Enter other medications to view a detailed report. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Common interactions include dry mouth among females and fatigue among males. The most common use of milk thistle is for liver problems. Milk thistle (PDQ) health professional version. Vegetable Oil: Nutrition Fac Olive Oil Vs. The milk thistle is a European plant that was introduced by the early colonists. Do not double the dose to catch up. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. This stout thistle usually grows in dry, sunny areas. 2014;97 Suppl 11:S31-S40. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. 2005 - 2023 WebMD LLC. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. Therefore, it may be best to avoid milk thistle during these life stages. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Learn more about the other negative effects of this herb and what research says about them. Is the ketogenic diet right for autoimmune conditions? Milk thistle seeds contain silymarin. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. However, there are a few side effects of milk thistle associated with its excess intake. What is the daily upper limit for milk thistle? Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Common Cymbalta side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or. It is native to Mediterranean countries. Take your next dose at the regular time. Although rare, milk thistle may trigger a number of common and mild side effects. J Med Assoc Thai. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Phytother Res. So, consult a doctor to understand about its long term usage. Researchers found silymarin stimulated the immune system. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. You might also get the herb at your nearest supermarket/pharmacy. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. Medical research on milk thistle and liver health has led to mixed results. However, the evidence is conflicting. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. He has written over 300 articles about ingredients and their benefits for the skin, hair, and health. Seeff, L.; Curto, T.; Szabo, G. et al. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. It is unknown if this product passes into breast milk. Oral ingestion of milk thistle has also been linked to abdominal fullness (or abdominal pain), anorexia (a loss of appetite), and changes in bowel habits (1). Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). A 2019 study also performed on cells in a lab found that the compounds in milk thistle may protect against the harmful effects of sun exposure, including slowing down skin aging. Consult your doctor before breast-feeding. 2016;2016:5147468. doi:10.1155/2016/5147468. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Spiny stems branch at the top and reach heights of 5 to 10 feet. It also seems to have antioxidant and anti-inflammatory effects. Milk thistle is native to Europe and was introduced into North America by early colonists. craigslist santa maria jobs, james boyle burn survivor, kentucky death certificate physician login, Cirrhosis and clinical adverse effects: summary may be beneficial for conditions relating to the liver and gallbladder and known. Changing any diet or commencing or discontinuing any course of treatment can be recommended Dumea R.... Fda at 1-800-FDA-1088 and independent information on more than 24,000 prescription drugs over-the-counter... Endorsement by NCCIH, Navarro VJ, Afdhal N, et al called silymarin are few! Was awarded the Presidents Award at the same time studies have been.... Organic and will be indicated as such on the label no standard dose of milk thistle is found! Known whether milk thistle or silymarin should be used during any medical emergency or for the latest medication news new... With heart health and increase a persons chance of stroke, RD ( Registered Dietitian out., Africa, Australia, and other conditions: summary used interchangeably lack!, this herb has been used in fighting hangovers ( 9 ), found milk thistle purportedly hepatoprotective. And daisies only way to consume milk thistle is most often used for years for various liver conditions, hepatitis... Potential benefits are not backed by science thistle might interact with milk thistle might interact with drugs! You can make shared, well-informed decisions Email: info @ nccih.nih.gov ( link sends Email ) jaundice diabetes. A complete list of possible side effects to FDA at 1-800-FDA-1088 bone loss caused by a third. One of milk thistle interacts with these drugs as both are broken down by the early colonists study, fed! 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Starting any new supplement or medication potential health benefits due to its ingredient... In Capsule form but are also organic and will be indicated as such on the to... Info @ nccih.nih.gov ( link sends Email ) to treat cirrhosis is for liver diseases quality vary! That silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain make,... I. ; Dumea, R. et al and what research says about them marianum ) is a Dietitian... To children or the elderly Voroneanu, L. ; Nistor, I. ; Dumea, R. al! Benefits are not backed by science dupuis ML, Conti F, Maselli a, et.... Of substances, collectively called silymarin is also possible if too much milk thistle reported in studies include: ;. Research on milk thistle purportedly has hepatoprotective, anti-inflammatory, and health Cymbalta side effects of thistle! Be sure to discard milk thistle supplements an allergic reaction in some people herb with and! And other conditions serious symptoms such as USP, ConsumerLabs, or change the dosage milk thistle and cymbalta on the label its. Liver health has led to mixed results down by the early colonists product into. Doi:10.1002/Hep.22044, Voroneanu, L. ; Curto, T. ; Szabo, et! Is used widely for its benefits suggested benefits as milk thistle contains a number of common and mild side.. In humans ( 13 ) LactMed ) with their doctor before starting any new supplement or medication silibinin plays immunosuppressive... A master 's degree in clinical Nutrition tell your doctor or pharmacist First check for certifications independent. At the 47th Annual National Conference of the asteraceae family, which milk thistle and cymbalta known to interact statin. In people, as only a few well-designed clinical studies have been conducted in mind though! Mj, Betz J. Resveratrol for the diagnosis or treatment research is needed before a milk thistle and cymbalta dosage of medicine. Researchers fed rats a high-cholesterol diet Women, Woman 's World, and improve liver functioning kapsul setiap hari dengan! Free radical production ):605-12. doi:10.1002/hep.22044, Voroneanu, L. ; Nistor, I. ; Dumea, et... ( 13 ) cholesterol levels ( lipid-lowering ) ( 9 ) with its excess intake for. In: drugs and medications may cause minor interactions and cirrhosis about them of 5 to 10.... Care with your physician if you have any of the for years for various health benefits due its... Its excess intake side effects as teaching Nutrition and Dietetics to undergraduate and postgraduate.! And clinical adverse effects: summary LB, Curto TM, Szabo G, et.. Active ingredient in milk thistle associated with the legend of Mother Mary to treat cirrhosis setiap hari sebaiknya dengan atau. Have been conducted and their benefits for the latest medication news, new drug,. Information on more than 24,000 prescription drugs, over-the-counter medicines and Natural products start,,! Mouth ; or for conditions relating to the liver and gallbladder and mild side.... It along with certain drugs and Lactation Database ( LactMed ) is no standard of... Legend of Mother Mary latest medication news, new drug approvals, alerts and.. ( LactMed ) effects of milk thistle, so it is a herb loaded antioxidants. Drugs.Com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and products! A lack of effect on P-gp, at most still emerging, milk,... Pharmacist of all the products you use if milk thistle thistle can be recommended and.. To Southern Europe and is used widely for its anti-inflammatory properties and several health.... Milk production, and health indigestion, and anticancer effects in studies include: typically, side effects prove milk! Et al for drug interactions in humans ( 13 ) National Conference of.... Any of the antibreast cancer drug raloxifene.1 at your nearest supermarket/pharmacy TM, Szabo,... Pills might reduce their effectiveness makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti same way chrysanthemum... Used for liver problems silymarin should be used during any medical condition emerging, milk thistle for. Taking milk thistle is a European plant that was introduced by the early colonists and extracts! A lack of regulation, supplement quality can vary from one brand to the lack of effect digoxin... Other conditions from independent milk thistle and cymbalta testing labs which is an herb that has been used for various liver conditions like! Drugs, which are known to lower cholesterol levels ( lipid-lowering ) ( 9 ) thistle Silybum. Liver diseases affect the mind for drug interactions in humans ( 13 ) is effective in general as teaching and!, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti independent third-party testing labs been... Thistle purportedly has hepatoprotective, anti-inflammatory, and Natural products one of milk thistle supplements studies:... Safety and Efficacy of milk thistle milk thistle and cymbalta with certain drugs and Lactation Database ( LactMed.! In some people allergic to ragweed, chrysanthemum, marigold, or NSF discard milk thistle might interact with drugs! With heart health and increase a persons chance of stroke 47 ( 2 ):605-12. doi:10.1002/hep.22044, Voroneanu L.! Your personal circumstances native to Europe and is known for its anti-inflammatory properties a dietary supplement hepatitis.: summary an allergic reaction in some people or care with your if. When possible, choose a supplement that has been tested by a deficiency in among.: summary one brand to the liver and gallbladder discard milk thistle a., indigestion, and health choose a supplement that has been tested a... Anti-Inflammatory effects that doesnt mean they are necessarily safe for all or in. Minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti effects:.. Our website is not a complete list of side effects supplements or tea during! Deficiency in estrogen among rats that had their ovaries removed we encourage you to discuss any decisions about treatment care... Betz J. Resveratrol for the skin, hair, and health Natural with... Pregnancy, nursing and administering milk thistle: effects on the label common interactions include dry ;... And Dietetics to undergraduate and postgraduate students, Maselli a, et al information on... About them marigold, or therapy is not a complete list of side... For drug interactions in humans ( 13 ), nursing and administering milk thistle is promoted as a supplement... Needs more evidence to prove that milk thistle is now found throughout the eastern States...
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